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Çѱ¹ÀÎ ¼Ò¾ÆÀÇ Å¸¾×¿¡¼­ Helicobacter pyloriÀÇ °ËÃâ

Detection of Helicobacter Pylori in Saliva of Korean Infant

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À¯Áö¿ø, ÀÌÀå±Ù, ÀÌ¿µ¼ö, À±Ã¢·ú, ¾ÈÁ¾¸ð,
¼Ò¼Ó »ó¼¼Á¤º¸
À¯Áö¿ø ( Ryu Ji-Won ) - Á¶¼±´ëÇб³ Ä¡°ú´ëÇÐ ±¸°­³»°úÇб³½Ç
ÀÌÀå±Ù ( Lee Jang-Keun ) - Á¶¼±´ëÇб³ Ä¡°ú´ëÇÐ ±¸°­³»°úÇб³½Ç
ÀÌ¿µ¼ö ( Lee Young-Su ) - Á¶¼±´ëÇб³ Ä¡°ú´ëÇÐ ±¸°­³»°úÇб³½Ç
À±Ã¢·ú ( Yoon Chang-Lyuk ) - Á¶¼±´ëÇб³ Ä¡°ú´ëÇÐ ±¸°­³»°úÇб³½Ç
¾ÈÁ¾¸ð ( Ahn Jong-Mo ) - Á¶¼±´ëÇб³ Ä¡°ú´ëÇÐ ±¸°­³»°úÇб³½Ç

Abstract

Helicobacter pylori(H. pylori)´Â À§¤ý½ÊÀÌÁöÀå ±Ë¾ç ¹× À§¾ÏÀÇ ¹ß»ý°ú °ü·ÃµÇ¾î ÀÖÀ¸¸ç, °¨¿°Àº ´ëºÎºÐ À¯³â±â¿¡ ¹ß»ýµÇ¾î ³ªÀÌ°¡ ¸Ô¾î°¨¿¡ µû¶ó Áõ°¡ÇÑ´Ù. °¨¿°°æ·Î¿¡ À־ ±¸°­Àº ¸Å¿ì Áß¿äÇÑ ¿ªÇÒÀ» Çϱ⠶§¹®¿¡ ¼Ò¾ÆÀÇ Å¸¾×¿¡¼­ H. pyloriÀÇ ¹ßÇöÀ²À» Á¶»çÇÏ¿© °¨¿°°æ·Î¸¦ ±Ô¸íÇϱâ À§ÇØ À§Àå°ü°ú °ü·ÃµÈ Áõ»ó ¹× Àü½ÅÁúȯÀÌ ¾ø´Â 10¼¼ ÀÌÇÏ 20¸í°ú 10´ë 20¸íÀÇ ½ÇÇ豺°ú 20¼¼ ÀÌ»ó 71¸íÀÇ ´ëÁ¶±ºÀ» ´ë»óÀ¸·Î ¿¬±¸ÇÏ¿´´Ù. 10¼¼ ¹Ì¸¸¿¡¼­ 5¸í(25%), 10´ë¿¡¼­ 6¸í(30%) ±×¸®°í 20¼¼ ÀÌ»ó 17¸í(23.9%)¿¡¼­ H. pylori°¡ Ÿ¾×¿¡¼­ °ËÃâµÇ¾ú´Ù. ½ÇÇ豺°ú ´ëÁ¶±º°£ÀÇ °ËÃâÀ² ºñ±³¿¡ À־ Â÷ÀÌ´Â ¾ø¾ú´Ù(P£¾0.05).
ÀÌ»óÀÇ °á°ú¸¦ Á¾ÇÕÇØ º¼ ¶§ °Ç°­ÇÑ Çѱ¹ÀÎ ¼Ò¾ÆÀÇ Å¸¾× ³»¿¡¼­ H. pylori´Â ºñ±³Àû ÈçÈ÷ Á¸ÀçÇϸç, ±¸°­ÀÌ H. pylori °¨¿°¿¡ ±Ù¿øÀÌ µÉ ¼ö ÀÖÀ½À» Ãß·ÐÇÒ ¼ö ÀÖ´Ù.

Helicobacter pylori(H. pylori) has been associated with the cause of peptic ulcer and gastric cancer. H. pylori infection occur mostly during childhood and increase by aging. In route of transmission, Oral cavity does important role. So we employed this study to elucidate route of transmission by detection of H. pylori in infant saliva. We investigated 20 infants aged below 10 years and 20 teens aged below 20 years as study group and 71 adults aged 20 and over years as control group. H. pylori DNA was isolated from 5(25%) infants aged below 10 years, 6(30%) teens and 17(23.9%) adults by nested polymerase chain reaction(n-PCR). There was no statistically significant difference(P£¾0.05). The obtained results suggest that H. pylori infection is relatively common in saliva of Korean infant and oral cavity may be reservoir of H. pylori.

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Helicobacter pylori;H.Pylori infection;Infant;Saliva

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